Ralph A Tripp Selected Research

GTP-Binding Proteins (G-Protein)

7/2017	The Central Conserved Region (CCR) of Respiratory Syncytial Virus (RSV) G Protein Modulates Host miRNA Expression and Alters the Cellular Response to Infection.
10/2015	Layer-By-Layer Nanoparticle Vaccines Carrying the G Protein CX3C Motif Protect against RSV Infection and Disease.
9/2015	An anti-G protein monoclonal antibody treats RSV disease more effectively than an anti-F monoclonal antibody in BALB/c mice.
9/2014	Prophylaxis with a respiratory syncytial virus (RSV) anti-G protein monoclonal antibody shifts the adaptive immune response to RSV rA2-line19F infection from Th2 to Th1 in BALB/c mice.
10/2013	A respiratory syncytial virus (RSV) anti-G protein F(ab')2 monoclonal antibody suppresses mucous production and breathing effort in RSV rA2-line19F-infected BALB/c mice.
1/2013	Decrease in formalin-inactivated respiratory syncytial virus (FI-RSV) enhanced disease with RSV G glycoprotein peptide immunization in BALB/c mice.
11/2012	Respiratory syncytial virus modifies microRNAs regulating host genes that affect virus replication.
1/2012	Combination therapy using monoclonal antibodies against respiratory syncytial virus (RSV) G glycoprotein protects from RSV disease in BALB/c mice.
9/2010	Prophylactic treatment with a G glycoprotein monoclonal antibody reduces pulmonary inflammation in respiratory syncytial virus (RSV)-challenged naive and formalin-inactivated RSV-immunized BALB/c mice.
1/2010	Vaccination to induce antibodies blocking the CX3C-CX3CR1 interaction of respiratory syncytial virus G protein reduces pulmonary inflammation and virus replication in mice.

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Ralph A Tripp Research Topics

Disease

62	Infections 01/2022 - 07/2002
36	Human Influenza (Influenza) 01/2022 - 08/2008
31	Respiratory Syncytial Virus Infections 01/2022 - 05/2002
15	Virus Diseases (Viral Diseases) 07/2022 - 01/2003
12	Pneumonia (Pneumonitis) 01/2021 - 07/2002
5	COVID-19 01/2022 - 01/2021
5	Inflammation (Inflammations) 03/2017 - 07/2002
5	Respiratory Tract Infections (Respiratory Tract Infection) 12/2016 - 10/2013
4	Influenza in Birds (Avian Flu) 12/2017 - 01/2011
4	Poliomyelitis (Polio) 10/2017 - 01/2016
3	Orthomyxoviridae Infections 12/2021 - 05/2011
3	Weight Loss (Weight Reduction) 01/2018 - 10/2013
3	Lung Diseases (Lung Disease) 02/2015 - 09/2003
2	Pulmonary Eosinophilia (Eosinophilic Pneumonia) 02/2015 - 09/2003
1	Severe Acute Respiratory Syndrome 11/2022
1	Bronchiolitis 01/2021
1	Cytokine Release Syndrome 01/2021
1	acute flaccid myelitis 10/2017
1	Osteoarthritis 11/2016
1	Stupor 08/2016

Drug/Important Bio-Agent (IBA)

29	VaccinesIBA 10/2021 - 12/2004
18	Proteins (Proteins, Gene)FDA Link 07/2022 - 09/2004
18	CytokinesIBA 12/2021 - 05/2002
15	GTP-Binding Proteins (G-Protein)IBA 07/2017 - 12/2004
14	Antiviral Agents (Antivirals)IBA 01/2022 - 02/2006
10	MicroRNAs (MicroRNA)IBA 11/2021 - 01/2012
9	AntibodiesIBA 01/2019 - 09/2003
8	Pharmaceutical PreparationsIBA 07/2022 - 01/2007
7	Hemagglutinins (Hemagglutinin)IBA 12/2020 - 10/2013
7	ChemokinesIBA 06/2012 - 01/2005
6	InterferonsIBA 12/2021 - 06/2009
6	Monoclonal AntibodiesIBA 01/2018 - 05/2009
5	Neuraminidase (Sialidase)IBA 01/2022 - 01/2011
5	EpitopesIBA 01/2022 - 09/2005
5	Respiratory Syncytial Virus VaccinesIBA 01/2020 - 09/2003
5	Glycoproteins (Glycoprotein)IBA 01/2019 - 07/2002
4	Interleukin-6 (Interleukin 6)IBA 01/2021 - 04/2011
4	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)IBA 09/2014 - 01/2013
4	Peptides (Polypeptides)IBA 03/2014 - 07/2002
4	Substance PIBA 10/2013 - 07/2002
3	Viral ProteinsIBA 01/2022 - 01/2013
3	hypothiocyanite ion (OSCN-)IBA 01/2022 - 01/2016
3	RNA (Ribonucleic Acid)IBA 01/2021 - 12/2004
3	Palivizumab FDA Link 01/2018 - 09/2015
3	verdinexorIBA 01/2018 - 09/2014
3	Interleukin-8 (Interleukin 8)IBA 03/2017 - 02/2007
3	EnzymesIBA 11/2016 - 01/2013
3	AntigensIBA 08/2015 - 05/2014
3	Formaldehyde (Formol)FDA Link 02/2015 - 09/2003
3	Neutralizing AntibodiesIBA 10/2013 - 08/2009
2	Probenecid (Benemid)FDA LinkGeneric 10/2021 - 01/2013
2	Indicators and Reagents (Reagents)IBA 01/2021 - 09/2004
2	Dual OxidasesIBA 01/2021 - 01/2016
2	Interleukin-10 (Interleukin 10)IBA 01/2021 - 05/2005
2	Interferon Type IIBA 01/2019 - 06/2009
2	thiocyanateIBA 01/2018 - 01/2016
2	Amino Acids FDA Link 11/2015 - 09/2005
2	MucinsIBA 09/2015 - 10/2013
2	AcidsIBA 05/2015 - 02/2007
2	Tryptophan (L-Tryptophan)FDA Link 04/2014 - 07/2013
2	N-Acetylneuraminic Acid (Sialic Acid)IBA 05/2011 - 01/2011
2	AerosolsIBA 04/2011 - 03/2011
2	Influenza Vaccines (Influenza Vaccine)FDA Link 03/2011 - 01/2009
2	Chemokine CCL5IBA 01/2011 - 05/2002
2	Small Interfering RNA (siRNA)IBA 01/2009 - 12/2008
2	Messenger RNA (mRNA)IBA 10/2008 - 05/2002
2	InterleukinsIBA 02/2007 - 05/2002
2	Interferon-gamma (Interferon, gamma)IBA 02/2007 - 05/2002
1	Protease Inhibitors (Protease Inhibitor)IBA 11/2022
1	Amantadine (Aman)FDA LinkGeneric 01/2022
1	nirsevimabIBA 01/2022
1	Ion Channels (Ion Channel)IBA 11/2021
1	Viral RNAIBA 01/2021
1	Losartan (Cozaar)FDA LinkGeneric 01/2021
1	CatalaseIBA 01/2021
1	Membrane Glycoproteins (Membrane Glycoprotein)IBA 01/2021
1	Nuclear Proteins (Protein, Nuclear)IBA 01/2021
1	Nucleic AcidsIBA 01/2021
1	Transfer RNA (tRNA)IBA 01/2021
1	Clopidogrel (Plavix)FDA Link 01/2021
1	Deubiquitinating EnzymesIBA 01/2021
1	Triamterene (Dyrenium)FDA LinkGeneric 01/2021
1	selinexorIBA 01/2021
1	Small Untranslated RNAIBA 01/2021
1	Biological ProductsIBA 11/2020
1	Exportin 1 ProteinIBA 01/2018
1	IodidesIBA 01/2018
1	Synthetic Vaccines (Recombinant Vaccines)IBA 12/2017
1	bindaritIBA 03/2017
1	Ribavirin (Virazole)FDA LinkGeneric 01/2017
1	Aggrecans (Aggrecan)IBA 11/2016
1	Proteoglycans (Proteoglycan)IBA 11/2016
1	Metalloproteases (Metalloproteinases)IBA 11/2016
1	Versicans (Versican)IBA 11/2016
1	Thrombospondin 1IBA 11/2016
1	DisintegrinsIBA 11/2016
1	Attenuated VaccinesIBA 03/2016
1	Poliovirus VaccinesIBA 03/2016

Therapy/Procedure

6	Therapeutics 01/2022 - 04/2012
1	Anesthesia 08/2016